John L. Morkovski, who served as the Bishop of Amarillo from 1958-1963, saw a need for a church in northwest Amarillo.

Thus, began the formation of St. Hyacinth parish in 1960.
 
The church/school was built on land donated by the Bush Estate in northwest Amarillo. Sam Houston Middle School and a Quonset hut behind the Veteran’s Hospital were used for services until the school building was completed. One of the rooms of the school building was used for worship services until the parish was able to build a church. On May 9, 1962, the dedication of the new facility took place.
 
The parish was staffed by priest and sisters of the Dominican Order and the Extension Society of Lay Teachers from 1960-1971. The school was closed in 1967 due to the closing of Amarillo Air Force Base which had a direct bearing on student enrollment.
 
A new church building was constructed and was dedicated on June 2, 1985. Final payment was made on the building on March 1, 1996. Renovation of the church offices and the kitchen areas took place in 1996-1997 and again in 2017.
 
Dominican Priests who served at St. Hyacinth are:
 
Rev. Martin M. Scannell, O.P.         1960-1962 Pastor
Rev. Michael A Kavannaugh, O.P.  1961-1963 Associate
Rev. Robert A. Kilbridge, O.P.         1963-1969 Pastor
Rev. Richard E. Trutter, O.P.           1969-1970 Pastor

With the departure of the Dominicans, Diocesan priest were assigned to the church:

 
Rev. James Comiskey                    1971-1978 Pastor
Rev. Dermot O’Brien                      1974-1978 Associate
Rev. Donald Rusch                         1978-1980 Pastor
Rev. Msgr. Peter DiBenedetto          1980-1995 Pastor
Rev. Bill Brashears                         1982-1984 Associate
Rev. Phil Lindley                            1984-1986 Parochial Vicar
Rev. Richard Scully                        1990-1991 Parochial Vicar
Rev. Bert Horvath                          1993-2000 Parochial Vicar
Rev. Patrick Carathers                    1996-2005 Pastor
Rev. Msgr. Raymond Crosier            2005-2011 Pastor
Rev. James Schmitmeyer                2011-2018 Pastor
Rev. Barnabus Radke                      2011-2014 Associate Pastor
Rev. Jose Ricardo Zanetti                2018-2019 Pastor
Rev. Guadalupe Mayorga                2019-2024, Administrator                                                 V. V. Rev. Jose Ricardo Zanetti, JCL     2024-Present, Pastor